Innovative Methodology Reinforcing operandum: rapid and reliable learning of skilled forelimb movements by head-fixed rodents
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چکیده
Rie Kimura,* Akiko Saiki,* Yoko Fujiwara-Tsukamoto,* Fuki Ohkubo, Kazuo Kitamura, Masanori Matsuzaki, Yutaka Sakai, and Yoshikazu Isomura Brain Science Institute, Tamagawa University, Machida, Tokyo, Japan; Graduate School of Brain Sciences, Tamagawa University, Machida, Tokyo, Japan; JST CREST, Chiyoda-ku, Tokyo, Japan; Laboratory of Neural Circuitry, Graduate School of Brain Science, Doshisha University, Kizugawa, Kyoto, Japan; Division of Brain Circuits, National Institute for Basic Biology and The Graduate University of Advanced Studies (Sokendai), Okazaki, Aichi, Japan; and Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
منابع مشابه
Reinforcing operandum: rapid and reliable learning of skilled forelimb movements by head-fixed rodents.
Stereotaxic head fixation plays a necessary role in current physiological techniques, such as in vivo whole cell recording and two-photon laser-scanning microscopy, that are designed to elucidate the cortical involvement in animal behaviors. In rodents, however, head fixation often inhibits learning and performance of behavioral tasks. In particular, it has been considered inappropriate for hea...
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Motor skills represent high-precision movements performed at optimal speed and accuracy. Such motor skills are learned with practice over time. Besides practice, effects of motivation have also been shown to influence speed and accuracy of movements, suggesting that fast movements are performed to maximize gained reward over time as noted in previous studies. In rodents, skilled motor performan...
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Knutsen, Per Magne, Dori Derdikman, and Ehud Ahissar. Tracking whisker and head movements in unrestrained behaving rodents. J Neurophysiol 93: 2294–2301, 2005. First published November 24, 2004; doi:10.1152/jn.00718.2004. Due to recent advances that enable real-time electrophysiological recordings in brains of awake behaving rodents, effective methods for analyzing the large amount of behaviora...
متن کاملOn the origin of skilled forelimb movements.
Homologizing behaviour was once considered unreliable, but the application of modern comparative methods has been shown to provide strong evidence of behavioural homologies. Skilled forelimb movements were thought to originate in the primate lineage but in fact are common among tetrapod taxa and probably share a common origin in early tetrapods. Furthermore, skilled movements are likely to have...
متن کاملDifferent Modulation of Common Motor Information in Rat Primary and Secondary Motor Cortices
Rodents have primary and secondary motor cortices that are involved in the execution of voluntary movements via their direct and parallel projections to the spinal cord. However, it is unclear whether the rodent secondary motor cortex has any motor function distinct from the primary motor cortex to properly control voluntary movements. In the present study, we quantitatively examined neuronal a...
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تاریخ انتشار 2012